Impact of pneumococcal conjugate vaccine and the severity of winter influenza-like illnesses on invasive pneumococcal infections in children and adults

Pediatr Infect Dis J. 2005 Jan;24(1):10-6. doi: 10.1097/01.inf.0000148930.41928.0d.


Background: Pneumococcal conjugate vaccine (PCV7), recommended in July 2000 for routine use in infants, has resulted in a reduction in the rate of invasive pneumococcal disease (IPD) in young children. We studied the impact of PCV7 and the possible contribution of the severity of influenza-like respiratory infection season on the rate of IPD on children and adults.

Methods: In 7 hospitals of a health system, episodes of IPD were identified by the microbiology laboratories during the 2-year period before July 2000 and the 4-year period after July 2000 during routine use of PCV7, and patient records were reviewed. Episodes of influenza-like illnesses during each winter in a local county were prospectively measured by reports from all acute care hospitals and episodes of absenteeism resulting from influenza-like illnesses from all schools.

Results: There were 720 patients with blood and/or cerebrospinal fluid isolates of Streptococcus pneumoniae. There were significant reductions in cases of IPD in children younger than 2 years, 68% reduction; children 2-4 years of age, 70%; adults 18-49 years of age, 42%; and adults older than 64 years, 30%. Annually, during the PCV7 period, there were significantly fewer episodes of influenza-like illnesses than during the pre-PCV7 years.

Conclusions: PCV7 efficacy and resultant herd-type immunity resulted in a reduction in the rate of IPD not only in young children but also in young and elderly adults. Milder winter respiratory viral seasons may possibly have contributed to the observed reduction in the rate of IPD.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child, Preschool
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Humans
  • Immunity, Herd
  • Incidence
  • Infant
  • Infant, Newborn
  • Influenza, Human / epidemiology*
  • Influenza, Human / immunology
  • Influenza, Human / physiopathology
  • Meningococcal Vaccines / administration & dosage*
  • Middle Aged
  • Outcome Assessment, Health Care*
  • Pneumococcal Infections / epidemiology*
  • Pneumococcal Infections / prevention & control
  • Pneumococcal Vaccines / administration & dosage*
  • Respiratory Tract Infections / epidemiology*
  • Respiratory Tract Infections / etiology
  • Respiratory Tract Infections / immunology
  • Respiratory Tract Infections / physiopathology
  • Seasons
  • Severity of Illness Index
  • Vaccination


  • Heptavalent Pneumococcal Conjugate Vaccine
  • Meningococcal Vaccines
  • Pneumococcal Vaccines