Intramuscular triamcinolone for difficult asthma

Pediatr Pulmonol. 2005 May;39(5):421-5. doi: 10.1002/ppul.20176.


We treated a selected group of children attending a difficult asthma clinic with intramuscular triamcinolone acetonide. This study retrospectively reviews markers of asthma severity in those who received one or more monthly doses for three periods: 1) 3 months preceding the first injection (pretreatment), 2) from the first injection to 1 month after the last injection (treatment period), and 3) 3 months after the treatment period (follow-up period). Severity markers during the treatment and follow-up periods were compared with the pretreatment period by paired t-test. Five children (5-13 years old) received a single dose, and 8 children (12-15 years old) received multiple doses. Multiple doses of triamcinolone (n = 3-5) were associated with a fall in the number of asthma exacerbations (P < 0.01) and hospital admissions (P < 0.01) in both the treatment and follow-up periods. A single dose reduced exacerbations (P < 0.05, treatment vs. pretreatment) but not hospital admissions. We conclude that intramuscular triamcinolone is a useful short-term therapy in difficult asthma. Whether its efficacy is due to improved compliance, or an improved anti-inflammatory profile compared with oral steroids, remains unclear.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Anti-Inflammatory Agents / administration & dosage*
  • Anti-Inflammatory Agents / therapeutic use
  • Asthma / drug therapy*
  • Asthma / physiopathology
  • Biomarkers / analysis
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Glucocorticoids / administration & dosage*
  • Glucocorticoids / therapeutic use
  • Humans
  • Injections, Intramuscular
  • Male
  • Patient Admission
  • Prednisolone / therapeutic use
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Triamcinolone Acetonide / administration & dosage*


  • Anti-Inflammatory Agents
  • Biomarkers
  • Glucocorticoids
  • Prednisolone
  • Triamcinolone Acetonide