The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis: a historical review

Br J Haematol. 2005 Feb;128(3):303-9. doi: 10.1111/j.1365-2141.2004.05291.x.


Angiogenesis is a biological process by which new capillaries are formed and it occurs in many physiological and pathological conditions. It is controlled by the net balance between molecules that have positive and negative regulatory activity and this concept had led to the notion of the 'angiogenic switch', depending on an increased production of one or more of the positive regulators of angiogenesis. Numerous inducers of angiogenesis have been identified and this review offers a historical account of the relevant literature concerning the discovery of one of the best characterized angiogenic factors, namely vascular endothelial growth factor (VEGF)/vascular permeability factor. Moreover, different strategies, designed to stimulate and to inhibit VEGF production in the context of several potential therapeutical implications, are discussed.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inducing Agents / therapeutic use
  • Angiogenesis Inhibitors / therapeutic use
  • History, 20th Century
  • Humans
  • Neoplasms / blood supply
  • Neoplasms / drug therapy
  • Neovascularization, Pathologic / history*
  • Neovascularization, Pathologic / physiopathology
  • Neovascularization, Physiologic / physiology*
  • Vascular Diseases / drug therapy
  • Vascular Endothelial Growth Factor A / history*
  • Vascular Endothelial Growth Factor A / physiology


  • Angiogenesis Inducing Agents
  • Angiogenesis Inhibitors
  • Vascular Endothelial Growth Factor A