The role of type X collagen in facilitating and regulating endochondral ossification of articular cartilage

Orthod Craniofac Res. 2005 Feb;8(1):11-7. doi: 10.1111/j.1601-6343.2004.00308.x.


AUTHOR: Shen G Objective -This review was compiled to explore the role of type X collagen in growth, development and remodeling of articular cartilage by elucidating the linkage between the synthesis of this protein and the phenotypic changes in chondrogenesis and the onset of endochondral ossification.

Design: The current studies closely dedicated to elucidating the role of type X collagen incorporating into chondrogenesis and endochondral ossification of articular cartilage were assessed and analyzed to allow for obtaining the mainstream consensus on the bio-molecular mechanism with which type X collagen functions in articular cartilage.

Results: There are spatial and temporal correlations between synthesis of type X collagen and occurrence of endochondral ossification. The expression of type X collagen is confined within hypertrophic condrocytes and precedes the embark of endochondral bone formation. Type X collagen facilitates endochondral ossification by regulating matrix mineralization and compartmentalizing matrix components.

Conclusion: Type X collagen is a reliable marker for new bone formation in articular cartilage. The future clinical application of this collagen in inducing or mediating endochondral ossification is perceived, e.g. the fracture healing of synovial joints and adaptive remodeling of madibular condyle.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Development / physiology*
  • Bone Matrix / metabolism
  • Calcification, Physiologic / physiology
  • Cartilage, Articular / physiology*
  • Chondrocytes / metabolism
  • Chondrogenesis / physiology
  • Collagen Type X / biosynthesis
  • Collagen Type X / genetics
  • Collagen Type X / physiology*
  • Humans
  • Mandibular Condyle / metabolism


  • Collagen Type X