Progression of diabetic retinopathy in pregnancy: association with hypertension in pregnancy

Am J Obstet Gynecol. 1992 Apr;166(4):1214-8. doi: 10.1016/s0002-9378(11)90608-5.


Objective: To test the hypothesis that women with insulin-dependent diabetes and chronic or pregnancy-induced hypertensive disorders are at increased risk for developing retinopathic complications during pregnancy.

Study design: One hundred fifty-four women with insulin-dependent diabetes were prospectively followed in an intensive program of diabetes in pregnancy. Ophthalmologic evaluations were obtained through pregnancy and at 6 to 12 weeks post partum, and findings were graded by a standard scale. Association of retinopathic progression with risk factors was tested with chi 2 and multiple logistic regression analysis.

Results: Fifty-one women had progression of retinopathy during pregnancy; postpartum regression was observed in 13 women. Changes in glycemic control early in pregnancy, chronic hypertension, and pregnancy-induced hypertension were significantly associated with progression of retinopathy.

Conclusion: Women with insulin-dependent diabetes who have hypertensive disorders in pregnancy are at increased risk for progression of retinopathy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Diabetes Mellitus, Type 1
  • Diabetes, Gestational*
  • Diabetic Retinopathy / complications
  • Diabetic Retinopathy / pathology*
  • Female
  • Humans
  • Hypertension / complications*
  • Pregnancy
  • Pregnancy Complications, Cardiovascular*
  • Pregnancy in Diabetics*
  • Prospective Studies
  • Regression Analysis