Skin cancer: lights on genome lesions

Curr Biol. 2005 Jan 26;15(2):R58-61. doi: 10.1016/j.cub.2004.12.056.

Abstract

Sunlight generates skin damage mainly by inducing DNA lesions in epidermal cells. The recent development of transgenic mice expressing specific photolyases has identified cyclobutane pyrimidine dimers as the major player in ultraviolet-induced damage, including skin cancer.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • DNA Damage / radiation effects*
  • DNA Repair Enzymes / metabolism
  • Mice
  • Mice, Transgenic
  • Models, Biological
  • Mutagenesis
  • Pyrimidine Dimers / metabolism*
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / metabolism
  • Sunlight*
  • Ultraviolet Rays*

Substances

  • Pyrimidine Dimers
  • pyrimidine-pyrimidone dimer
  • DNA Repair Enzymes