MicroRNA biogenesis: drosha can't cut it without a partner

Curr Biol. 2005 Jan 26;15(2):R61-4. doi: 10.1016/j.cub.2004.12.057.

Abstract

The ribonuclease Drosha requires a dedicated double-stranded RNA binding protein to convert long, nuclear primary microRNA transcripts into shorter pre-microRNA stem-loops, the cytoplasmic precursors from which mature microRNAs are ultimately excised.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Humans
  • MicroRNAs / biosynthesis*
  • MicroRNAs / metabolism
  • Proteins / metabolism*
  • RNA-Binding Proteins / metabolism*
  • Ribonuclease III / metabolism*

Substances

  • DGCR8 protein, human
  • MicroRNAs
  • Proteins
  • RNA-Binding Proteins
  • DROSHA protein, human
  • Ribonuclease III