RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women

Cancer Lett. 2005 Feb 10;218(2):191-7. doi: 10.1016/j.canlet.2004.09.023.


The RAD52 gene is involved in the homologous recombination repair pathway and is a plausible candidate ovarian cancer predisposition gene. We undertook a case-control comparison of 508 epithelial ovarian cancer cases (91 low malignant potential and 417 invasive) and 298 healthy controls to assess the RAD52 Y415X polymorphism as a risk factor for epithelial ovarian cancer in Australian women. Heterozygote frequencies of 2.6 and 4% were observed among cases and controls, respectively. The risk estimate was 0.55 (95%CI 0.24-1.24), suggesting that the RAD52 Y415X polymorphism is not associated with epithelial ovarian cancer in Australian women.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Genotype
  • Humans
  • Middle Aged
  • Neoplasms, Glandular and Epithelial / etiology
  • Neoplasms, Glandular and Epithelial / genetics*
  • Ovarian Neoplasms / etiology
  • Ovarian Neoplasms / genetics*
  • Polymorphism, Genetic*
  • Rad52 DNA Repair and Recombination Protein / genetics*
  • Risk Factors


  • RAD52 protein, human
  • Rad52 DNA Repair and Recombination Protein