Serum gastrin concentrations in colorectal cancer patients

Ann R Coll Surg Engl. 1992 Mar;74(2):138-40; discussion 141.


Fasting serum gastrin concentrations were shown to be elevated in colorectal cancer patients compared with controls (P = 0.0037), which was mainly accounted for by a subgroup of patients who had significantly elevated levels. In cancer patients there was no difference in gastrin concentrations in blood taken from a tumour-draining mesenteric vein and from a peripheral vein at the time of colonic resection. Serum gastrin concentrations were significantly lower after apparently curative resection for colorectal cancer (P = 0.028), suggesting that the elevated serum gastrin seen in these patients may be due, at least in part, to secretion of gastrin by the tumour.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Colorectal Neoplasms / blood*
  • Colorectal Neoplasms / surgery
  • Fasting / blood
  • Gastrins / blood*
  • Humans
  • Mesenteric Veins
  • Middle Aged
  • Postoperative Period


  • Gastrins