Genetic study of the CD36 gene in a French diabetic population

Diabetes Metab. 2004 Nov;30(5):459-63. doi: 10.1016/s1262-3636(07)70143-x.


Objectives: CD36 is a multifunctional membrane receptor widely expressed in different tissues which binds and internalizes oxidized low-density lipoprotein. In rodents, CD36 gene variations modulate glucose homeostasis and contribute to metabolic syndrome associated with type 2 diabetes but the effects in human are unknown.

Methods: We screened the entire coding sequence of the CD36 gene in 272 individuals and we genotyped both rare and frequent variants in 454 T2D subjects and 221 controls.

Results: We detected five mutations, P191P and N247S were only found each in one family and did not segregate with diabetes, the three others (A/C-178 in the promoter, A/G-10 in intron 3 and (GGGTTGAGA) insertion in intron 13) being equally frequent in diabetic subjects and in controls. However, adiponectin levels, a marker for insulin sensitivity, were significantly associated with the -178 A/C promoter variant allele (p=0.003, p corrected for multiple testing=0.036), possibly reflecting association with insulin-resistance in the French population.

Conclusion: Thus, the -178 A/C SNP promoter mutation in the CD36 gene represents a putative genetic marker for insulin-resistance in the French population, although it does not appear to contribute to the genetic risk for T2D.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin
  • Base Sequence
  • CD36 Antigens / genetics*
  • Diabetes Mellitus / genetics*
  • Diabetes Mellitus / immunology
  • Exons / genetics
  • France
  • Genetic Variation*
  • Genotype
  • Humans
  • Insulin Resistance / genetics
  • Intercellular Signaling Peptides and Proteins / blood
  • Introns / genetics
  • Mutation*
  • Polymorphism, Single Nucleotide / genetics
  • Promoter Regions, Genetic
  • Reference Values


  • Adiponectin
  • CD36 Antigens
  • Intercellular Signaling Peptides and Proteins