Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, regulation of proteolysis, and implications for drug development

Megan L Kerr; David H Small

doi:10.1002/jnr.20408

Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, regulation of proteolysis, and implications for drug development

J Neurosci Res. 2005 Apr 15;80(2):151-9. doi: 10.1002/jnr.20408.

Authors

Megan L Kerr¹, David H Small

Affiliation

¹ Laboratory of Molecular Neurobiology, Department of Biochemistry and Molecular Biology, and Monash University Centre for Brain and Behaviour, Monash University, Victoria, Australia.

PMID: 15672415
DOI: 10.1002/jnr.20408

Abstract

The beta-amyloid protein precursor (APP) has been extensively studied for its role in amyloid production and the pathogenesis of Alzheimer's disease (AD). However, little is known about the normal function of APP and its biological interactions. In this Mini-Review, the role of the cytoplasmic domain of APP in APP trafficking and proteolysis is described. These studies suggest that proteins that bind to the cytoplasmic domain may be important targets for drug development in AD.

2005 Wiley-Liss, Inc.

Publication types

Review

MeSH terms

Alzheimer Disease / genetics
Alzheimer Disease / metabolism*
Amino Acid Sequence
Amyloid beta-Protein Precursor / chemistry*
Amyloid beta-Protein Precursor / genetics
Amyloid beta-Protein Precursor / metabolism
Amyloid beta-Protein Precursor / physiology*
Animals
Cytoplasm / genetics
Cytoplasm / metabolism*
Drug Delivery Systems / methods*
Drug Design*
Humans
Hydrolysis
Molecular Sequence Data
Peptide Hydrolases / metabolism
Protein Transport

Substances

Amyloid beta-Protein Precursor
Peptide Hydrolases