Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation

Clin Exp Med. 2004 Oct;4(2):78-85. doi: 10.1007/s10238-004-0041-4.

Abstract

The anti-tumor activity of the immune system in the setting of hematopoietic stem cell transplantation has largely been described in the context of the "graft-versus-tumor" effect of allogeneic stem cell transplantation. This article reviews clinical evidence suggesting the existence of an autologous graft-versus-tumor effect in the setting of host immune system recovery following autologous stem cell transplantation resulting in prolongation of survival of cancer patients.

Publication types

  • Review

MeSH terms

  • Graft vs Tumor Effect / immunology*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immunocompetence*
  • Killer Cells, Natural / immunology
  • Lymphocyte Count
  • Transplantation, Autologous
  • Transplantation, Homologous