Effect of antagonists vs agonists on in vitro fertilization outcome

Clin Exp Obstet Gynecol. 2004;31(4):257-9.

Abstract

Purpose: To compare outcome following in vitro fertilization-embryo transfer (IVF-ET) using controlled ovarian hyperstimulation (COH) regimens using either the gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate vs the GnRH antagonist ganirelix.

Methods: Women needing IVF for conception were randomly assigned to 300 IU of gonadotropins with ganirelix used in the follicular phase when a follicle with a 14 mm average diameter was attained vs a regimen using leuprolide acetate from the mid-luteal phase of the previous cycle.

Results: There were no differences found in clinical, ongoing, delivered pregnancy rates or implantation rates between groups.

Conclusions: The use of GnRH antagonists do not seem to reduce IVF outcome compared to using GnRH agonists in COH regimens.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Dose-Response Relationship, Drug
  • Embryo Transfer / statistics & numerical data
  • Female
  • Fertility Agents, Female / therapeutic use*
  • Fertilization in Vitro / methods*
  • Follicle Stimulating Hormone, beta Subunit / therapeutic use
  • Follicular Phase
  • Gonadotropin-Releasing Hormone / analogs & derivatives*
  • Gonadotropin-Releasing Hormone / antagonists & inhibitors
  • Gonadotropin-Releasing Hormone / therapeutic use*
  • Hormone Antagonists / therapeutic use*
  • Humans
  • Leuprolide / therapeutic use*
  • Luteal Phase
  • Menotropins / therapeutic use
  • Pregnancy
  • Pregnancy Rate
  • Prospective Studies

Substances

  • Fertility Agents, Female
  • Follicle Stimulating Hormone, beta Subunit
  • Hormone Antagonists
  • Gonadotropin-Releasing Hormone
  • Menotropins
  • Leuprolide
  • ganirelix