Analysis of upstream sequences of the human estrogen receptor gene

Biochem Biophys Res Commun. 1992 Mar 31;183(3):996-1002. doi: 10.1016/s0006-291x(05)80289-x.


An upstream region of the human estrogen receptor gene (ER) spanning from -2776 to -38 in relation to a previously described exon 1 was sequenced and analyzed for the possible presence of open reading frames (ORF) and regulatory motifs. We identified a long 459 bp ORF beginning at -2301. Most of the transcriptional regulatory motifs present within the ER upstream sequence are distributed either upstream or downstream of this long ORF which displays a TATA box, a CACC motif and a canonical cap site in the 5' flanking region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosome Mapping
  • Humans
  • Molecular Sequence Data
  • Reading Frames
  • Receptors, Estrogen / genetics*
  • Regulatory Sequences, Nucleic Acid / genetics*
  • Sequence Homology, Nucleic Acid
  • Transcription, Genetic


  • Receptors, Estrogen

Associated data

  • GENBANK/D10272
  • GENBANK/D10273
  • GENBANK/D10274
  • GENBANK/D10275
  • GENBANK/D10276
  • GENBANK/S88464
  • GENBANK/S88466
  • GENBANK/S88468
  • GENBANK/X63118
  • GENBANK/X68051