Hyperimmunoglobulinemia D syndrome in an Arab child

Clin Rheumatol. 2005 Feb;24(1):92-4. doi: 10.1007/s10067-004-0953-0. Epub 2004 Jul 8.


Hyperimmunoglobulinemia D syndrome (HIDS) is newly recognized and resembles familial Mediterranean fever (FMF). It is inherited as an autosomal recessive trait. Mutation of the gene coding for mevalonate kinase is responsible for the disease. The gene is located at chromosome 12q24. The patients initially described were of Dutch ancestry. Other cases from Turkey and Armenia were reported. The case we present is the first from Arab countries to be registered in the International HIDS Registry and to our knowledge the first to be reported.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Child
  • DNA / analysis
  • Diagnosis, Differential
  • Familial Mediterranean Fever / blood
  • Familial Mediterranean Fever / diagnosis*
  • Familial Mediterranean Fever / genetics
  • Humans
  • Hypergammaglobulinemia / blood
  • Hypergammaglobulinemia / diagnosis*
  • Hypergammaglobulinemia / genetics
  • Immunoglobulin D* / blood
  • Male
  • Middle East
  • Mutation / genetics
  • Phosphotransferases (Alcohol Group Acceptor) / blood
  • Phosphotransferases (Alcohol Group Acceptor) / genetics
  • Recurrence
  • Retrospective Studies
  • Sequence Analysis, DNA


  • Immunoglobulin D
  • DNA
  • Phosphotransferases (Alcohol Group Acceptor)
  • mevalonate kinase