Abstract
We recently described two novel aryl binding sites of farnesyltransferase. The 4- and 5-arylsubstituted thienylacryloyl moieties turned out as appropriate substituents for our benzophenone-based AAX-peptidomimetic capable for occupying the far aryl binding site.
MeSH terms
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Acrylamides / chemistry*
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Alkyl and Aryl Transferases / antagonists & inhibitors*
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Alkyl and Aryl Transferases / chemistry*
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Benzophenones / chemistry*
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Binding Sites
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Farnesyltranstransferase
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Structure-Activity Relationship
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Thiophenes / chemistry*
Substances
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Acrylamides
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Benzophenones
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Thiophenes
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Alkyl and Aryl Transferases
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Farnesyltranstransferase