Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2005 Feb;124(2):304-7.
doi: 10.1111/j.0022-202X.2004.23560.x.

Ultraviolet B-induced DNA Damage in Human Epidermis Is Modified by the Antioxidants Ascorbic Acid and D-alpha-tocopherol

Affiliations
Free article
Clinical Trial

Ultraviolet B-induced DNA Damage in Human Epidermis Is Modified by the Antioxidants Ascorbic Acid and D-alpha-tocopherol

Marianne Placzek et al. J Invest Dermatol. .
Free article

Abstract

DNA damage caused by ultraviolet (UV) irradiation is considered the main etiologic factor contributing to the development of skin cancer. Systemic or topical application of antioxidants has been suggested as a protective measure against UV-induced skin damage. We investigated the effect of long-term oral administration of a combination of the antioxidants ascorbic acid (vitamin C) and D-alpha-tocopherol (vitamin E) in human volunteers on UVB-induced epidermal damage. The intake of vitamins C and E for a period of 3 mo significantly reduced the sunburn reaction to UVB irradiation. Detection of thymine dimers in the skin using a specific antibody revealed a significant increase of this type of DNA damage following UVB exposure. After 3 mo of antioxidant administration, significantly less thymine dimers were induced by the UVB challenge, suggesting that antioxidant treatment protected against DNA damage.

Similar articles

See all similar articles

Cited by 19 articles

  • Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials.
    Jeter JM, Bowles TL, Curiel-Lewandrowski C, Swetter SM, Filipp FV, Abdel-Malek ZA, Geskin LJ, Brewer JD, Arbiser JL, Gershenwald JE, Chu EY, Kirkwood JM, Box NF, Funchain P, Fisher DE, Kendra KL, Marghoob AA, Chen SC, Ming ME, Albertini MR, Vetto JT, Margolin KA, Pagoto SL, Hay JL, Grossman D, Ellis DL, Kashani-Sabet M, Mangold AR, Markovic SN, Meyskens FL Jr, Nelson KC, Powers JG, Robinson JK, Sahni D, Sekulic A, Sondak VK, Wei ML, Zager JS, Dellavalle RP, Thompson JA, Weinstock MA, Leachman SA, Cassidy PB. Jeter JM, et al. Cancer. 2019 Jan 1;125(1):18-44. doi: 10.1002/cncr.31719. Epub 2018 Oct 3. Cancer. 2019. PMID: 30281145 Free PMC article. Review.
  • Oral Photoprotection: Effective Agents and Potential Candidates.
    Parrado C, Philips N, Gilaberte Y, Juarranz A, González S. Parrado C, et al. Front Med (Lausanne). 2018 Jun 26;5:188. doi: 10.3389/fmed.2018.00188. eCollection 2018. Front Med (Lausanne). 2018. PMID: 29998107 Free PMC article. Review.
  • Nutraceuticals for Skin Care: A Comprehensive Review of Human Clinical Studies.
    Pérez-Sánchez A, Barrajón-Catalán E, Herranz-López M, Micol V. Pérez-Sánchez A, et al. Nutrients. 2018 Mar 24;10(4):403. doi: 10.3390/nu10040403. Nutrients. 2018. PMID: 29587342 Free PMC article. Review.
  • The Roles of Vitamin C in Skin Health.
    Pullar JM, Carr AC, Vissers MCM. Pullar JM, et al. Nutrients. 2017 Aug 12;9(8):866. doi: 10.3390/nu9080866. Nutrients. 2017. PMID: 28805671 Free PMC article. Review.
  • Melanoma Chemoprevention: Current Status and Future Prospects.
    Chhabra G, Ndiaye MA, Garcia-Peterson LM, Ahmad N. Chhabra G, et al. Photochem Photobiol. 2017 Jul;93(4):975-989. doi: 10.1111/php.12749. Epub 2017 Apr 27. Photochem Photobiol. 2017. PMID: 28295364 Free PMC article. Review.
See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback