Inferring the mode of speciation from genomic data: a study of the great apes

Genetics. 2005 Jan;169(1):259-64. doi: 10.1534/genetics.104.029231.

Abstract

The strictly allopatric model of speciation makes definable predictions on the pattern of divergence, one of which is the uniformity in the divergence time across genomic regions. Using 345 coding and 143 intergenic sequences from the African great apes, we were able to reject the null hypothesis that the divergence time in the coding sequences (CDSs) and intergenic sequences (IGSs) is the same between human and chimpanzee. The conclusion is further supported by the analysis of whole-genome sequences between these species. The difference suggests a prolonged period of genetic exchange during the formation of these two species. Because the analysis should be generally applicable, collecting DNA sequence data from many genomic regions between closely related species should help to settle the debate over the prevalence of the allopatric mode of speciation.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • DNA, Intergenic / genetics*
  • Evolution, Molecular
  • Genetic Variation*
  • Genome*
  • Gorilla gorilla / genetics*
  • Humans
  • Open Reading Frames / genetics*
  • Pan troglodytes / genetics*
  • Time

Substances

  • DNA, Intergenic