Abstract
Clamp loaders are heteropentameric ATPase assemblies that load sliding clamps onto DNA and are critical for processive DNA replication. The DNA targets for clamp loading are double-stranded/single-stranded junctions with recessed 3' ends (primer-template junctions). Here, we briefly review the crystal structures of clamp loader complexes and the insights they have provided into the mechanism of the clamp loading process.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenosine Triphosphatases / chemistry*
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Adenosine Triphosphatases / metabolism*
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Adenosine Triphosphate / metabolism
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DNA / metabolism
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DNA Polymerase III / metabolism
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DNA Replication / physiology*
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DNA-Binding Proteins / chemistry*
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DNA-Binding Proteins / metabolism*
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DNA-Directed DNA Polymerase / metabolism*
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Models, Molecular
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Protein Conformation
Substances
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DNA-Binding Proteins
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Adenosine Triphosphate
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DNA
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beta subunit, DNA polymerase III
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DNA Polymerase III
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DNA-Directed DNA Polymerase
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Adenosine Triphosphatases