DNA polymerase clamp loaders and DNA recognition

FEBS Lett. 2005 Feb 7;579(4):863-7. doi: 10.1016/j.febslet.2004.11.038.


Clamp loaders are heteropentameric ATPase assemblies that load sliding clamps onto DNA and are critical for processive DNA replication. The DNA targets for clamp loading are double-stranded/single-stranded junctions with recessed 3' ends (primer-template junctions). Here, we briefly review the crystal structures of clamp loader complexes and the insights they have provided into the mechanism of the clamp loading process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphatases / chemistry*
  • Adenosine Triphosphatases / metabolism*
  • Adenosine Triphosphate / metabolism
  • DNA / metabolism
  • DNA Polymerase III / metabolism
  • DNA Replication / physiology*
  • DNA-Binding Proteins / chemistry*
  • DNA-Binding Proteins / metabolism*
  • DNA-Directed DNA Polymerase / metabolism*
  • Models, Molecular
  • Protein Conformation


  • DNA-Binding Proteins
  • Adenosine Triphosphate
  • DNA
  • beta subunit, DNA polymerase III
  • DNA Polymerase III
  • DNA-Directed DNA Polymerase
  • Adenosine Triphosphatases