The mammalian Mediator complex

FEBS Lett. 2005 Feb 7;579(4):904-8. doi: 10.1016/j.febslet.2004.11.031.


The multiprotein Mediator (Med) complex is an evolutionarily conserved transcriptional regulator that plays important roles in activation and repression of RNA polymerase II transcription. Prior studies identified a set of more than twenty distinct polypeptides that compose the Saccharomyces cerevisiae Mediator. Here we discuss efforts to characterize the subunit composition and associated activities of the mammalian Med complex.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Mammals / metabolism
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / metabolism
  • Protein Subunits
  • Proteomics
  • Trans-Activators / chemistry*
  • Trans-Activators / metabolism*


  • Multiprotein Complexes
  • Protein Subunits
  • Trans-Activators