Screening of dementia in stroke patients with lacunar infarcts: comparison of the mattis dementia rating scale and the mini-mental state examination

J Geriatr Psychiatry Neurol. 2005 Mar;18(1):3-7. doi: 10.1177/0891988704269814.


There have been no data on the performance of the Initiation-Perseveration subtest of the Mattis Dementia Rating Scale (MDRS-IP) in screening poststroke dementia (PSDE). Three months after the index stroke, a research assistant administered the MDRS-IP and Mini-Mental State Examination (MMSE) to 83 Chinese stroke patients with lacunar infarcts who were consecutively admitted to the stroke unit of a general hospital. A psychiatrist, who was blind to the MDRS-IP and MMSE scores, interviewed all 83 patients and made a Diagnostic and Statistical Manual of Mental Disorders (4th edition) diagnosis of dementia, which served as the benchmark for judging the performance of MDRSIP. The optimal cutoff point of MDRS-IP was 22/23. The sensitivity, specificity, and positive and negative predictive values of MDRS-IP, and the area under the receiver operating characteristic curve were 82%, 90%, 0.41, 0.98, and 0.91, respectively. The overall performance of the MDRS-IP was comparable to the MMSE.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Brain Infarction / complications*
  • Brain Infarction / psychology
  • Case-Control Studies
  • Dementia / diagnosis*
  • Dementia / etiology
  • Diagnosis, Differential
  • False Negative Reactions
  • Female
  • Humans
  • Interview, Psychological
  • Male
  • Mental Status Schedule*
  • Middle Aged
  • Predictive Value of Tests
  • Psychiatric Status Rating Scales*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Stroke / complications*
  • Stroke / psychology