Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetes

Ann N Y Acad Sci. 2004 Dec:1029:331-3. doi: 10.1196/annals.1309.038.

Abstract

Insulin peptide B:9-23 (amino acids 9 to 23 of the B chain) can induce immune targeting of insulin and islets in normal Balb/c mice. The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin.

MeSH terms

  • Administration, Oral
  • Animals
  • Antigens, CD
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / drug therapy
  • Diabetes Mellitus, Type 1 / immunology*
  • Disease Models, Animal
  • Injections, Subcutaneous
  • Insulin / administration & dosage*
  • Insulin / therapeutic use*
  • Insulin Antibodies / blood*
  • Integrin alpha Chains
  • Mice
  • Mice, Inbred BALB C
  • Peptide Fragments / administration & dosage*
  • Peptide Fragments / therapeutic use*

Substances

  • Antigens, CD
  • Insulin
  • Insulin Antibodies
  • Integrin alpha Chains
  • Peptide Fragments
  • alpha E integrins
  • insulin B (9-30)