Abstract
Insulin peptide B:9-23 (amino acids 9 to 23 of the B chain) can induce immune targeting of insulin and islets in normal Balb/c mice. The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin.
MeSH terms
-
Administration, Oral
-
Animals
-
Antigens, CD
-
Diabetes Mellitus, Type 1 / blood
-
Diabetes Mellitus, Type 1 / drug therapy
-
Diabetes Mellitus, Type 1 / immunology*
-
Disease Models, Animal
-
Injections, Subcutaneous
-
Insulin / administration & dosage*
-
Insulin / therapeutic use*
-
Insulin Antibodies / blood*
-
Integrin alpha Chains
-
Mice
-
Mice, Inbred BALB C
-
Peptide Fragments / administration & dosage*
-
Peptide Fragments / therapeutic use*
Substances
-
Antigens, CD
-
Insulin
-
Insulin Antibodies
-
Integrin alpha Chains
-
Peptide Fragments
-
alpha E integrins
-
insulin B (9-30)