A promoter deletion reduces the rate of mitotic, but not meiotic, recombination at the HIS4 locus in yeast

Curr Genet. 1992 Feb;21(2):109-16. doi: 10.1007/BF00318468.


Several investigators have reported that transcription stimulates some types of mitotic recombination in the yeast Saccharomyces cerevisiae. We find that mutations that reduce the rate of transcription of the yeast HIS4 gene in vegetative cells reduce the frequency of mitotic, but not meiotic, recombination events.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blotting, Northern
  • Gene Conversion*
  • Genes, Fungal
  • Kinetics
  • Meiosis
  • Mitosis
  • Mutation*
  • Promoter Regions, Genetic*
  • Restriction Mapping
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / physiology
  • Spores, Fungal
  • Transcription, Genetic