Absence of pulmonary uptake of Tc-99m methylenediphosphonate in alveolar microlithiasis

Ann Nucl Med. 2004 Dec;18(8):695-8. doi: 10.1007/BF02985964.


Pulmonary alveolar microlithiasis (PAM) is a rare disease of unknown etiology characterized by accumulation of calcific concretions in the alveolar spaces. The paper reports a case of PAM in a 56-year-old male. The patient had persistent dry cough, and gradually progressive dyspnea on exertion. The diagnosis was established on the basis of roentgenography and confirmed by the sputum and transbronchial biopsy findings. Scintigraphy revealed the absence of Tc-99m methylenediphosphonate uptake of lungs. Familial occurrence was not observed. Chest roentgenogram, pulmonary function, and clinical status of the patient have remained stable for 41 months. Radiological and clinical follow-up of the disease continues.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Lithiasis / diagnostic imaging*
  • Lithiasis / metabolism*
  • Lung / diagnostic imaging*
  • Lung / metabolism*
  • Lung Diseases / diagnostic imaging*
  • Lung Diseases / metabolism*
  • Male
  • Middle Aged
  • Pulmonary Alveoli / diagnostic imaging
  • Pulmonary Alveoli / metabolism
  • Radionuclide Imaging
  • Radiopharmaceuticals / pharmacokinetics
  • Technetium Tc 99m Medronate / pharmacokinetics*


  • Radiopharmaceuticals
  • Technetium Tc 99m Medronate