Visual field defects during low-dose methotrexate therapy

Doc Ophthalmol. 1992;79(1):91-4. doi: 10.1007/BF00160135.


A patient was treated with low-dose methotrexate because of psoriasis that did not respond to conventional therapy. During treatment, visual symptoms occurred; optic disc swelling was found, and later slight optic disc atrophy. Moreover, paracentral relative visual field defects showed fluctuations parallel to methotrexate dose changes. It seems likely that methotrexate affected optic nerve function.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Methotrexate / adverse effects*
  • Methotrexate / therapeutic use
  • Optic Atrophy / chemically induced
  • Papilledema / chemically induced
  • Psoriasis / drug therapy
  • Vision Disorders / chemically induced*
  • Visual Fields*


  • Methotrexate