Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 184 (2), 291-318

Appetite Control

Affiliations
Review

Appetite Control

Katie Wynne et al. J Endocrinol.

Abstract

Our understanding of the physiological systems that regulate food intake and body weight has increased immensely over the past decade. Brain centres, including the hypothalamus, brainstem and reward centres, signal via neuropeptides which regulate energy homeostasis. Insulin and hormones synthesized by adipose tissue reflect the long-term nutritional status of the body and are able to influence these circuits. Circulating gut hormones modulate these pathways acutely and result in appetite stimulation or satiety effects. This review discusses central neuronal networks and peripheral signals which contribute energy homeostasis, and how a loss of the homeostatic process may result in obesity. It also considers future therapeutic targets for the treatment of obesity.

Similar articles

  • [Mechanisms of Regulation of the Food Intake: Recent Advances]
    A Loviselli et al. Recenti Prog Med 98 (1), 1-6. PMID 17345872. - Review
    The mechanisms deputed to energetic control have been selected by ancestral diets resulting from the nutrient disposal during the evolution. Discovery of the leptin and i …
  • Hormonal Regulation of Food Intake
    S Stanley et al. Physiol Rev 85 (4), 1131-58. PMID 16183909. - Review
    Our knowledge of the physiological systems controlling energy homeostasis has increased dramatically over the last decade. The roles of peripheral signals from adipose ti …
  • Hormonal Interactions Between Gut and Brain
    S Zac-Varghese et al. Discov Med 10 (55), 543-52. PMID 21189225. - Review
    No truly effective drugs exist to treat obesity, which is reaching pandemic proportions. The search for new treatments has led to an interest into the homeostatic system …
  • Appetite Signaling: From Gut Peptides and Enteric Nerves to Brain
    E Näslund et al. Physiol Behav 92 (1-2), 256-62. PMID 17582445. - Review
    The signaling systems underlying eating behavior control are complex. The current review focuses on gastrointestinal (GI) signaling systems as physiological key functions …
  • Gut Hormones and the Regulation of Energy Homeostasis
    KG Murphy et al. Nature 444 (7121), 854-9. PMID 17167473. - Review
    Food intake, energy expenditure and body adiposity are homeostatically regulated. Central and peripheral signals communicate information about the current state of energy …
See all similar articles

Cited by 105 PubMed Central articles

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources

Feedback