Profiling early head and neck cancer

Nat Rev Cancer. 2005 Feb;5(2):127-35. doi: 10.1038/nrc1549.


Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma, Squamous Cell / etiology
  • Carcinoma, Squamous Cell / metabolism*
  • Carcinoma, Squamous Cell / pathology
  • Cell Line, Tumor
  • Disease Progression
  • Gene Expression Regulation
  • Gene Expression Regulation, Neoplastic*
  • Head and Neck Neoplasms / etiology
  • Head and Neck Neoplasms / metabolism*
  • Head and Neck Neoplasms / pathology
  • Humans
  • Models, Biological
  • Mouth Neoplasms / metabolism
  • Mucous Membrane / pathology
  • Neoplasms / metabolism
  • Precancerous Conditions
  • Prognosis
  • Risk Factors
  • Stem Cells / cytology
  • Stem Cells / metabolism