A clinical trial of hydroxyethylrutosides in the treatment of haemorrhoids of pregnancy

J Int Med Res. 1992 Feb;20(1):54-60. doi: 10.1177/030006059202000107.

Abstract

The safety and efficacy of 500 mg O-(beta-hydroxyethyl)rutosides given orally twice daily in the treatment of 97 patients with first-, second-, or third-degree haemorrhoids were investigated in a double-blind, randomized placebo-controlled trial. The rutosides produced a significant (P less than 0.001) improvement in patient-assessed subjective symptoms (pain, bleeding, exudation and pruritus) compared with placebo. There was also a significant (P less than 0.001) improvement in clinician-assessed subjective and objective signs (bleeding, inflammation and dilatation of the haemorrhoidal plexus) after 2 and 4 weeks' treatment compared with placebo. There were three mild, transient side-effects reported in the active treatment group and no drug-related problems in the pregnancy or delivery were observed. The results suggest that O-(beta-hydroxyethyl)rutosides provide a safe and effective treatment for women with haemorrhoids of pregnancy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Double-Blind Method
  • Drug Tolerance
  • Female
  • Hemorrhoids / complications*
  • Hemorrhoids / drug therapy*
  • Humans
  • Hydroxyethylrutoside / administration & dosage
  • Hydroxyethylrutoside / adverse effects
  • Hydroxyethylrutoside / therapeutic use*
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / drug therapy*

Substances

  • Hydroxyethylrutoside