Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis

Br J Cancer. 2005 Feb 14;92(3):430-3. doi: 10.1038/sj.bjc.6602369.


A meta-analysis of six randomised trials demonstrated that intensive followup in colorectal cancer was associated with an absolute reduction in all-cause 5-year mortality of 10% (95% confidence interval (CI): 4-16)--however, only two percent (95% CI: 0-5) was attributable to cure from salvage re-operations. We postulate that other factors, such as increased psychological well-being and/or altered lifestyle, and/or improved treatment of coincidental disease may contribute to the remaining lives saved, and form important future research questions.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorectal Neoplasms / mortality*
  • Colorectal Neoplasms / psychology
  • Follow-Up Studies*
  • Humans
  • Models, Biological
  • Randomized Controlled Trials as Topic
  • Salvage Therapy
  • Survival Analysis