The pathogenesis of discogenic low back pain

J Bone Joint Surg Br. 2005 Jan;87(1):62-7.


Discogenic low back pain is a common cause of disability, but its pathogenesis is poorly understood. We collected 19 specimens of lumbar intervertebral discs from 17 patients with discogenic low back pain during posterior lumbar interbody fusion, 12 from physiologically ageing discs and ten from normal control discs. We investigated the histological features and assessed the immunoreactive activity of neurofilament (NF200) and neuropeptides such as substance P (SP) and vasoactive-intestinal peptide (VIP) in the nerve fibres. The distinct histological characteristic of the painful disc was the formation of a zone of vascularised granulation tissue from the nucleus pulposus to the outer part of the annulus fibrosus along the edges of the fissures. SP-, NF- and VIP-immunoreactive nerve fibres in the painful discs were more extensive than in the control discs. Growth of nerves deep into the annulus fibrosus and nucleus pulposus was observed mainly along the zone of granulation tissue in the painful discs. This suggests that the zone of granulation tissue with extensive innervation along the tears in the posterior part of the painful disc may be responsible for causing the pain of discography and of discogenic low back pain.

MeSH terms

  • Adult
  • Aging / pathology
  • Female
  • Granulation Tissue / pathology
  • Humans
  • Intervertebral Disc* / chemistry
  • Intervertebral Disc* / innervation
  • Intervertebral Disc* / pathology
  • Low Back Pain / etiology*
  • Low Back Pain / metabolism
  • Low Back Pain / pathology
  • Lumbar Vertebrae
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nerve Fibers / chemistry
  • Nerve Fibers / pathology
  • Neurofilament Proteins / analysis
  • Neuropeptides / analysis
  • Spinal Diseases / complications*
  • Spinal Fusion


  • Neurofilament Proteins
  • Neuropeptides
  • neurofilament protein H