Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein

Cell Res. 2005 Jan;15(1):19-23. doi: 10.1038/


Proteins like Raf kinase inhibitory protein (RKIP) that serve as modulators of signaling pathways, either by promoting or inhibiting the formation of productive signaling complexes through protein-protein interactions, have been demonstrated to play an increasingly important role in a number of cell types and organisms. These proteins have been implicated in development as well as the progression of cancer. RKIP is a particularly interesting regulator, as it is a highly conserved, ubiquitously expressed protein that has been shown to play a role in growth and differentiation in a number of organisms and can regulate multiple signaling pathways. RKIP is also the first MAP kinase signaling modulator to be identified as playing a role in cancer metastasis, and identification of the mechanism by which it regulates Raf-1 activation provides new targets for therapeutic intervention.

Publication types

  • Review

MeSH terms

  • Animals
  • Cattle
  • Cell Differentiation
  • Cell Proliferation
  • Disease Progression
  • Humans
  • MAP Kinase Signaling System*
  • Mice
  • Neoplasm Metastasis
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neurons / metabolism
  • Protein Kinase C / metabolism
  • Rats
  • Signal Transduction
  • raf Kinases / metabolism*


  • raf Kinases
  • Protein Kinase C