Mouse and guinea pig models for testing new tuberculosis vaccines

Tuberculosis (Edinb). Jan-Mar 2005;85(1-2):13-7. doi: 10.1016/j.tube.2004.08.001. Epub 2005 Jan 22.

Abstract

Animal models of pulmonary tuberculosis in the mouse and guinea pig contain to provide new information about the host response in the lungs, changes in immunopathology, and the protective effect of new vaccine candidates. These include Mtb72F, a polyprotein vaccine that gives excellent protection and also boosts and prolongs the protective effect of the BCG vaccine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • BCG Vaccine / immunology
  • BCG Vaccine / therapeutic use
  • Bacterial Proteins / immunology*
  • Bacterial Proteins / therapeutic use
  • Guinea Pigs
  • Humans
  • Mice
  • Mice, Inbred Strains
  • Models, Animal*
  • Mycobacterium tuberculosis / immunology*
  • T-Lymphocyte Subsets / immunology
  • Tuberculosis Vaccines / immunology
  • Tuberculosis Vaccines / therapeutic use*
  • Tuberculosis, Pulmonary / immunology
  • Tuberculosis, Pulmonary / pathology
  • Tuberculosis, Pulmonary / prevention & control*

Substances

  • BCG Vaccine
  • Bacterial Proteins
  • Tuberculosis Vaccines