Efficacy of lifestyle modification for long-term weight control

Obes Res. 2004 Dec;12 Suppl:151S-62S. doi: 10.1038/oby.2004.282.


A comprehensive program of lifestyle modification induces loss of approximately 10% of initial weight in 16 to 26 weeks, as revealed by a review of recent randomized controlled trials, including the Diabetes Prevention Program. Long-term weight control is facilitated by continued patient-therapist contact, whether provided in person or by telephone, mail, or e-mail. High levels of physical activity and the consumption of low-calorie, portion-controlled meals, including liquid meal replacements, can also help maintain weight loss. Additional studies are needed of the effects of macronutrient content (e.g., low-fat vs. low-carbohydrate diets) on long-term changes in weight and health. Research also is needed on effective methods of providing comprehensive weight loss control to the millions of Americans who need it.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Behavior Therapy
  • Body Weight*
  • Diet, Fat-Restricted
  • Diet, Reducing
  • Dietary Carbohydrates / administration & dosage
  • Energy Intake
  • Exercise
  • Food, Formulated
  • Humans
  • Internet
  • Life Style*
  • Obesity / therapy*
  • Randomized Controlled Trials as Topic
  • Telephone
  • Time Factors
  • Weight Gain


  • Dietary Carbohydrates