Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

Nat Rev Mol Cell Biol. 2005 Feb;6(2):112-26. doi: 10.1038/nrm1571.


The internalization of various cargo proteins and lipids from the mammalian cell surface occurs through the clathrin and lipid-raft endocytic pathways. Protein-lipid and protein-protein interactions control the targeting of signalling molecules and their partners to various specialized membrane compartments in these pathways. This functions to control the activity of signalling cascades and the termination of signalling events, and therefore has a key role in defining how a cell responds to its environment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Clathrin / chemistry
  • Clathrin / physiology*
  • Endocytosis
  • ErbB Receptors / metabolism
  • Glycosphingolipids / chemistry
  • Lipids / chemistry
  • Membrane Microdomains
  • Microscopy, Fluorescence
  • Models, Biological
  • Models, Chemical
  • Receptors, Transforming Growth Factor beta / metabolism
  • Signal Transduction*


  • Clathrin
  • Glycosphingolipids
  • Lipids
  • Receptors, Transforming Growth Factor beta
  • ErbB Receptors