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Review
, 6 (2), 150-66

Protein S-nitrosylation: Purview and Parameters

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Review

Protein S-nitrosylation: Purview and Parameters

Douglas T Hess et al. Nat Rev Mol Cell Biol.

Abstract

S-nitrosylation, the covalent attachment of a nitrogen monoxide group to the thiol side chain of cysteine, has emerged as an important mechanism for dynamic, post-translational regulation of most or all main classes of protein. S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation.

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