GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

Nat Rev Mol Cell Biol. 2005 Feb;6(2):167-80. doi: 10.1038/nrm1587.


Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate numerous cellular responses such as proliferation, differentiation and movement. With 69 distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho GTPases in humans, and they activate Rho GTPases within particular spatio-temporal contexts. The failure to do so can have significant consequences and is reflected in the aberrant function of Dbl-family GEFs in some human diseases.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Allosteric Site
  • Animals
  • Guanine Nucleotide Exchange Factors / chemistry*
  • Guanine Nucleotide Exchange Factors / metabolism
  • Humans
  • Lipid Bilayers / chemistry
  • Mice
  • Models, Biological
  • Models, Molecular
  • Neurons / metabolism
  • Phylogeny
  • Protein Binding
  • Protein Structure, Tertiary
  • Signal Transduction
  • ras-GRF1 / chemistry
  • rho GTP-Binding Proteins / chemistry*


  • Guanine Nucleotide Exchange Factors
  • Lipid Bilayers
  • ras-GRF1
  • rho GTP-Binding Proteins