Review
doi: 10.1038/nrm1547.
Function and regulation of cullin-RING ubiquitin ligases
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- PMID: 15688063
- DOI: 10.1038/nrm1547
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Review
Function and regulation of cullin-RING ubiquitin ligases
Nat Rev Mol Cell Biol.
2005 Jan.
Abstract
Cullin-RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin-RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin-RING ligases, and describe how these enzymes can be characterized by a set of general principles.
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