Function and regulation of cullin-RING ubiquitin ligases

Nat Rev Mol Cell Biol. 2005 Jan;6(1):9-20. doi: 10.1038/nrm1547.


Cullin-RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin-RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin-RING ligases, and describe how these enzymes can be characterized by a set of general principles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cullin Proteins / chemistry
  • Cullin Proteins / physiology*
  • Humans
  • Protein Structure, Tertiary
  • Ubiquitin / physiology
  • Ubiquitin-Protein Ligases / chemistry
  • Ubiquitin-Protein Ligases / physiology*


  • Cullin Proteins
  • Ubiquitin
  • Ubiquitin-Protein Ligases

Associated data

  • PDB/1LDK