ADAMs: key components in EGFR signalling and development

Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43. doi: 10.1038/nrm1548.


ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored metalloproteases that process and shed the ectodomains of membrane-anchored growth factors, cytokines and receptors. ADAMs also have essential roles in fertilization, angiogenesis, neurogenesis, heart development and cancer. Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Dimerization
  • ErbB Receptors / physiology*
  • Heart / embryology
  • Humans
  • Metalloendopeptidases / physiology*
  • Molecular Sequence Data
  • Neovascularization, Physiologic / physiology
  • Signal Transduction / physiology*


  • ErbB Receptors
  • Metalloendopeptidases