p53: traffic cop at the crossroads of DNA repair and recombination

Nat Rev Mol Cell Biol. 2005 Jan;6(1):44-55. doi: 10.1038/nrm1546.


p53 mutants that lack DNA-binding activities, and therefore, transcriptional activities, are among the most common mutations in human cancer. Recently, a new role for p53 has come to light, as the tumour suppressor also functions in DNA repair and recombination. In cooperation with its function in transcription, the transcription-independent roles of p53 contribute to the control and efficiency of DNA repair and recombination.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / physiology
  • Animals
  • DNA Helicases / physiology
  • DNA Repair / physiology*
  • DNA-Binding Proteins / physiology
  • Humans
  • RecQ Helicases
  • Recombination, Genetic / physiology*
  • Tumor Suppressor Protein p53 / physiology*


  • DNA-Binding Proteins
  • Tumor Suppressor Protein p53
  • XPC protein, human
  • Adenosine Triphosphatases
  • RECQL protein, human
  • DNA Helicases
  • RecQ Helicases