Multicomponent therapeutics for networked systems

Nat Rev Drug Discov. 2005 Jan;4(1):71-8. doi: 10.1038/nrd1609.


Therapeutic regimens that comprise more than one active ingredient are commonly used in clinical medicine. Despite this, most drug discovery efforts search for drugs that are composed of a single chemical entity. A focus in the early drug discovery process on identifying and optimizing the activity of combinations of molecules can result in the identification of more effective drug regimens. A systems perspective facilitates an understanding of the mechanism of action of such drug combinations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Clinical Trials as Topic
  • Drug Design
  • Drug Synergism*
  • Drug Therapy, Combination*
  • Humans
  • Terminology as Topic