Macro trends in pharmaceutical innovation

Nat Rev Drug Discov. 2005 Jan;4(1):78-84. doi: 10.1038/nrd1610.


Critics decry the lack of 'truly innovative' new medicines and question the role of the pharmaceutical industry in creating the few that are developed. Is this an accurate portrayal of the state of pharmaceutical innovation? Does major pharma still innovate? If so, how? Must the industry innovate to survive? These and related issues are discussed.

Publication types

  • Review

MeSH terms

  • Clinical Trials as Topic / classification
  • Drug Industry / economics
  • Drug Industry / methods
  • Drug Industry / trends*
  • Humans
  • National Institutes of Health (U.S.)
  • Organizational Innovation*
  • Pharmaceutical Preparations / chemical synthesis
  • Pharmaceutical Preparations / classification
  • Pharmaceutical Preparations / economics
  • Technology Transfer*
  • United States
  • United States Food and Drug Administration


  • Pharmaceutical Preparations