Fibroblast growth factor signaling during early vertebrate development

Endocr Rev. 2005 Feb;26(1):63-77. doi: 10.1210/er.2003-0040.


Fibroblast growth factors (FGFs) have been implicated in diverse cellular processes including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and proliferation. This review presents our current understanding on the roles of FGF signaling, the pathways employed, and its regulation. We focus on FGF signaling during early embryonic processes in vertebrates, such as induction and patterning of the three germ layers as well as its function in the control of morphogenetic movements.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemotaxis
  • Embryonic Development / physiology*
  • Endoderm
  • Fibroblast Growth Factors / physiology*
  • Gastrula
  • Homeostasis
  • Humans
  • Mesoderm
  • Morphogenesis
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Fibroblast Growth Factor / physiology
  • Signal Transduction / physiology*


  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factors
  • Protein-Tyrosine Kinases