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Review
, 433 (7025), 477-80

Regulation of Cap-Dependent Translation by eIF4E Inhibitory Proteins

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Review

Regulation of Cap-Dependent Translation by eIF4E Inhibitory Proteins

Joel D Richter et al. Nature.

Abstract

Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5' ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.

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