Regulation of cap-dependent translation by eIF4E inhibitory proteins

Nature. 2005 Feb 3;433(7025):477-80. doi: 10.1038/nature03205.


Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5' ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Eukaryotic Initiation Factor-4E / antagonists & inhibitors*
  • Eukaryotic Initiation Factor-4E / metabolism
  • Gene Expression Regulation, Developmental
  • Humans
  • Neoplasms / metabolism
  • Nervous System / metabolism
  • Protein Biosynthesis*
  • RNA Caps / genetics
  • RNA Caps / metabolism*


  • Eukaryotic Initiation Factor-4E
  • RNA Caps