Rapid recurrence of nonalcoholic fatty liver disease after transplantation in a child with hypopituitarism and hepatopulmonary syndrome

Liver Transpl. 2005 Jan;11(1):108-10. doi: 10.1002/lt.20332.


Nonalcoholic fatty liver disease (NAFLD) has been reported in adults with hypothalamic or pituitary dysfunction, and some have progressed to end stage liver disease requiring transplantation. We report a teenager who initially presented with hypoxia due to intrapulmonary shunting, found to have NAFLD and cirrhosis associated with a hypothalamic tumor and panhypopituitarism. The NAFLD recurred very quickly after a successful liver transplant. Hepatopulmonary syndrome may be more common in cirrhosis associated with pituitary dysfunction than in other types of cirrhosis.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Fatty Liver / complications*
  • Fatty Liver / pathology*
  • Hepatopulmonary Syndrome / complications*
  • Humans
  • Hypopituitarism / complications*
  • Liver Transplantation*
  • Male
  • Postoperative Complications / pathology
  • Recurrence