A walk-through of the yeast mating pheromone response pathway

Peptides. 2005 Feb;26(2):339-50. doi: 10.1016/j.peptides.2004.10.002.


The intracellular signal transduction pathway by which the yeast Saccharomyces cerevisiae responds to the presence of peptide mating pheromone in its surroundings is one of the best understood signaling pathways in eukaryotes, yet continues to generate new surprises and insights. In this review, we take a brief walk down the pathway, focusing on how the signal is transmitted from the cell-surface receptor-coupled G protein, via a MAP kinase cascade, to the nucleus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review
  • Corrected and Republished Article

MeSH terms

  • Cell Cycle
  • Cell Membrane / metabolism
  • GTP-Binding Proteins / metabolism
  • MAP Kinase Kinase Kinases / metabolism
  • MAP Kinase Signaling System / physiology
  • Models, Biological
  • Pheromones / metabolism*
  • Receptors, Cell Surface / metabolism
  • Saccharomyces cerevisiae / metabolism*
  • Signal Transduction*


  • Pheromones
  • Receptors, Cell Surface
  • MAP Kinase Kinase Kinases
  • GTP-Binding Proteins