Ultrahigh-resolution optical coherence tomography in glaucoma

Ophthalmology. 2005 Feb;112(2):229-37. doi: 10.1016/j.ophtha.2004.08.021.


Objective: Optical coherence tomography (OCT) has been shown to be a valuable tool in glaucoma assessment. We investigated a new ultrahigh-resolution OCT (UHR-OCT) imaging system in glaucoma patients and compared the findings with those obtained by conventional-resolution OCT.

Design: Retrospective comparative case series.

Participants: A normal subject and 4 glaucoma patients representing various stages of glaucomatous damage.

Testing: All participants were scanned with StratusOCT (axial resolution of approximately 10 mum) and UHR-OCT (axial resolution of approximately 3 microm) at the same visit.

Main outcome measure: Comparison of OCT findings detected with StratusOCT and UHR-OCT.

Results: Ultrahigh-resolution OCT provides a detailed cross-sectional view of the scanned retinal area that allows differentiation between retinal layers. These UHR images were markedly better than those obtained by the conventional-resolution OCT.

Conclusions: Ultrahigh-resolution OCT provides high-resolution images of the ocular posterior segment, which improves the ability to detect retinal abnormalities due to glaucoma.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Diagnostic Techniques, Ophthalmological*
  • Female
  • Glaucoma, Open-Angle / diagnosis*
  • Humans
  • Male
  • Middle Aged
  • Nerve Fibers / pathology*
  • Optic Disk / pathology*
  • Optic Nerve Diseases / diagnosis*
  • Pilot Projects
  • Retinal Ganglion Cells / pathology*
  • Retrospective Studies
  • Tomography, Optical Coherence / instrumentation
  • Tomography, Optical Coherence / methods*