Are proteins made from a limited parts list?

Trends Biochem Sci. 2005 Feb;30(2):73-80. doi: 10.1016/j.tibs.2004.12.005.


Understanding the process of protein folding has been recognized as an important challenge for >70 years. It is, quintessentially, a thermodynamic problem and, arguably, thermodynamics is our most powerful discipline for understanding biological systems. Yet, despite all this, we still lack predictive understanding of protein folding. Is something missing from this picture?

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Hydrogen Bonding
  • Models, Molecular
  • Peptides / chemistry
  • Protein Conformation
  • Protein Folding*
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Proteins / chemistry*
  • Thermodynamics
  • Water / chemistry


  • Peptides
  • Proteins
  • Water
  • polyproline