RNA-polymerase-I-directed rDNA transcription, life and works

Trends Biochem Sci. 2005 Feb;30(2):87-96. doi: 10.1016/j.tibs.2004.12.008.


In the extensive network of interdependent biochemical processes required for cell growth and division, there is mounting evidence that ribosomal DNA transcription by RNA polymerase I (pol I) not only drives cell growth via its direct role in production of the ribosomal RNA (rRNA) component of the protein-synthesis machinery, but that it is also crucial in determining the fate of the cell. Considerable progress has been made in recent years towards understanding both the function of components of the pol I transcription machinery and how cells accomplish the tight control of pol I transcription, balancing the supply of rRNA with demand under different growth conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylation
  • Animals
  • Apoptosis / genetics
  • Apoptosis / physiology
  • Cell Cycle / genetics
  • Cell Cycle / physiology
  • Cell Enlargement
  • Cell Proliferation
  • DNA, Ribosomal / genetics*
  • Gene Expression Regulation / genetics
  • Humans
  • Models, Biological
  • Phosphorylation
  • Pol1 Transcription Initiation Complex Proteins / metabolism
  • RNA Polymerase I / metabolism*
  • Terminator Regions, Genetic / genetics
  • Transcription, Genetic / genetics*


  • DNA, Ribosomal
  • Pol1 Transcription Initiation Complex Proteins
  • transcription factor UBF
  • transcription initiation factor TIF-IB
  • RNA Polymerase I