A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage

J Am Acad Dermatol. 2005 Feb;52(2):268-74. doi: 10.1016/j.jaad.2004.06.021.


Background: Previous studies indicate that tazarotene is efficacious in reducing signs of photodamage. Objective We sought to confirm the efficacy and tolerability of tazarotene 0.1% cream in the treatment of facial photodamage.

Methods: A total of 568 patients with at least moderate fine wrinkling or mottled hyperpigmentation applied tazarotene 0.1% cream or vehicle cream to their face once daily for 24 weeks.

Results: Tazarotene cream was significantly more effective than vehicle in reducing fine wrinkles, mottled hyperpigmentation, lentigines, irregular depigmentation, apparent pore size, elastosis, tactile roughness, and an overall integrated assessment of photodamage. Significance was achieved as early as week 2 for some parameters and had not plateaued by week 24. The majority of patients reported improvements in their photodamage as early as week 4. Adverse events were predominantly mild or moderate signs or symptoms of skin irritation.

Conclusion: Once-daily tazarotene 0.1% cream is effective in ameliorating multiple signs of facial photodamage.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / adverse effects
  • Dermatologic Agents / therapeutic use*
  • Double-Blind Method
  • Facial Dermatoses / drug therapy*
  • Facial Dermatoses / etiology
  • Female
  • Humans
  • Hyperpigmentation / drug therapy*
  • Hyperpigmentation / etiology
  • Male
  • Middle Aged
  • Nicotinic Acids / administration & dosage
  • Nicotinic Acids / adverse effects
  • Nicotinic Acids / therapeutic use*
  • Skin Aging / drug effects*
  • Treatment Outcome
  • Ultraviolet Rays / adverse effects*


  • Dermatologic Agents
  • Nicotinic Acids
  • tazarotene